BIOLOGY 301 - FALL 2007
GENERAL GENETICS

LECTURE: T/Th, 9:10-10:25, MMC6

DISCUSSION SECTIONS (VCLS 224 - computer lab):
Section 1:
Wed., 9:10-10:25, Section 2: Wed, 12:00-1:15; Section 3: Wed, 4:15-5:30
URL: 
http://www.vancouver.wsu.edu/fac/bishop/home-long.html. Click on Biol 301

SCHEDULE

Academic Calendar

Links

National Center for Biotechnology Information

Glossary of genetic terms

Laptop Policy

Oct. 8: Nobel Prize awarded to scientists for development of gene targeting techniques.

Height Data

BRCA1 - New York Times article - what would you do if you have a mutant BRCA1?
New York Times Genetic Counseling article (from 9/18/07)

BLACKBOARD - You can view your grades on blackboard. Login with your network id and network id password.

Exam 1 Answers

Exam 2 Answers

Final Exam, answers on Bishop's part.

INSTRUCTORS:                                                                      
Dr. John Bishop

Dr. Tara Macey

CONTACT & OFFICE HOURS:

Dr. John Bishop   
Office: ELS 230E   
Office Hours: Mon 11-12Tue 10:30-12:00; Wed 10:30-11:30; Thurs 10:30-11:00

email: bishop<at>vancouver.wsu.edu
546-9612 (don't call to tell me you can't make it to class!)
John's Home Page

Dr. Tara Macey
Office: CL 316.
Office Hours: TBA & by appointment
email: macey<at>vancouver.wsu.edu

Teaching Assistant:

Abby Ventura

Office Hours: TBA. in ELS 201; drop in in ELS 213

Email: ventura<at>vancouver.wsu.edu

COURSE GOALS
This course will provide you with an overview of the two major branches of genetics, transmission genetics and molecular genetics, and an introduction to genomics. Our goal is for students to finish this class with the ability to understand the scientific underpinnings of modern issues in genetics, such as genetic engineering, genomics, crop breeding, cancer, and human genetic variation. Students will be prepared for more advanced coursework in genetics, evolution, and molecular biology.   This course satisfies prerequisite requirements for Zoo/Bot 405 (Evolution), MBios 360 (Cell and Molecular Laboratory), and MBios 401 (Cell Biology).

COURSE PREQUISITES
You MUST have completed WSU BIOL 106 and BIOL 107 or equivalent (Clark equivalents: BIOL 204, 205, & 206), AND Chemistry 105 and 106 or equivalent (Clark College equivalent: Chem 131, 132, and 133).

TEXBOOK
REQUIRED:   iGenetics, A Mendelian Approach by Peter J. Russell  REQUIRED: Fly-Lab subscription; OPTIONAL: Flylab Student Manual.

You can buy a FlyLab subscription online with a credit card. Go to http://www.biologylabsonline.com and click on Buy Now, and you'll have the online access right away. The cost is $7.00. Once you're subscribed, you can print the Flylab Student Manual (When you're logged into flylab, its "Background Information", "Introduction", and "Assignments" on the left sidebar. The abbreviations list is handy too.).

LAPTOPS IN LECTURE. Laptops are allowed in lecture as long as they do not become a distraction to the learning environment. TWO CAUTIONS: 1) The internet and IMing are like visual heroin - most of us are addicted, and if they are present, we will use them even when we should be doing something important. I suggest that most of you will do better if you keep your laptops shut and turn off your phones. Let's face it, its difficult to pay attention for 1:15 even to an exciting lecture, and if you slip over to email or surfing, you might as well not come to lecture. You should be aware that there is actually research indicating that students have less retention of typed material. 2) If laptop users become a distraction to me or others in the class, I will change the policy.

FORMAT
Reading: You must read the assigned reading BEFORE you come to lecture.  I will call on individual students to answer questions from reading, and will also employ unannounced quizzes. Lectures will not attempt to comprehensively cover or faithfully follow the readings.  Rather, they will focus on  concepts and details that are most important or difficult to understand. 

Problem solving is an essential part of this course.  The most important thing you can do in this class is to work the recommended problems. These problems will show up again on quizzes and similar problems will be on exams. Do not cram! Instead, spend time every day working genetics problems.  Learning and retention of material is far greater this way than by cramming.

Discussion section is mandatory and important. During this time we will focus on problem solving. Quizzes will be administered in discussion section.You must attend the discussion section in which you are enrolled.

Homework must be handed in at the beginning of the discussion section. The following penalties apply for handing in late homework: 0-2 hrs late: 33% off. By 5pm same day: 50% off. After 5pm: No credit.

Academic honesty. When a student enrolls in Washington State University, the student assumes an obligation to pursue academic endeavors in a manner consistent with the standards of academic integrity adopted by the University. To maintain the academic integrity of the community, the University cannot tolerate acts of academic dishonesty. Academic dishonesty includes cheating, falsification, fabrication, multiple submission, plagiarism**, abuse of academic materials, complicity, or misconduct in research.

Assignments completed outside of class MUST be your own work. Although some assignments may require cooperative work, the answers you turn in should still be your own. Academic dishonesty including copying and plagiarism** are serious offenses which will be reported to Student Services and entered into your permanent record. The policy of the College of Science is that anyone caught cheating will be given a grade of F for the entire course. A letter documenting the incident will be written to the Dean of the College and the Vice President for StudentAffairs. Two such offenses may result in expulsion from the University. Consult the WSU Student Handbook for further details.

You should be aware that text copied from web pages is particularly easy for us to trace and we usually can recognize when a student's writing is not his/her own. When using these information sources employ these strategies: 1) paraphrase what you read; 2) quote short sections, and 3) provide full references for quotes or for ideas that aren't yours.

** Plagiarism is defined as the unauthorized use of the language or thoughts of another person, and the representation of them as one's own. (Random House Webster's College Dictionary, 1991).

Disability Accommodation:  Accommodations may be available if you need them in order to fully participate in this class because of a disability. Accommodations may take some time to implement so it is critical that you contact Disability Services as soon as possible.  All accommodations must be approved through Disability Services, located in the Student Resource Center on the Lower Level of VSSC.  (360) 546-9138

GRADING
Your grade will be based on homework assignments, approximately seven quizzes, 3 in-class exams, and a final exam. About 50% of the final exam will be cumulative. The lowest scoring quiz will be dropped when calculating the Quiz grade for the class. Quizzes CANNOT be made up. Participation includes being prepared to answer questions during lecture. NOTE: The exact weighting of exams and weighting and number of quizzes, and other evaluation tools may be changed slightly. I will endeavor to keep in you informed of any changes.

Assignment

Points

7 Quizzes + 4-6 Homeworks

25%

3 Exams

50%

Final Exam

20%

Discussion, Micro-assignments, Participation

5%

TOTAL  

100%

Grades will be awarded on an absolute scale. In other words, we will not hesitate to give everyone an A if their percent score is high enough.   The following table shows how grades are scaled. You are responsible for keeping track of how you are doing in the class.

% of possible points

93-100

90-92.9

87-89.9

83-86.9

80-82.9

77-79.9

73-76.9

70-72.9

60-69.9

<60

Grade

A

A-

B+

B

B-

C+

C

C-

D

F

SCHEDULE
Check here frequently for syllabus changes and updates on readings and homework problems!

Week

Date

Reading

Topic

Wed.
Discussion

Problem sets/Study guide

1 Bish

Tu. Aug. 21

Lecture

Ch. 2

Mendelian Genetics

Mendelian Genetics

Pblm 2.22; Chi square; Intro to Fly Lab;

Study Guide Ch. 1-2

 

Th. Aug. 23

Pre-Lect figs

Ch. 2

Hmwk1 Answers (FlyLab)

 

Disc Aug. 22

 

Ch. 3 guide

2 Bish

Tu. Aug. 28

Download Acrobat Reader

Ch. 3

Mitosis, Meiosis

Fly Lab, Key Problems

Hmwk2 (FlyLab)

Answers

Th. Aug. 30

Slides

Ch. 3 Meiosis, Sex Linkage, Sex Determination
Article: genetics of handedness

 

Disc Aug 29  

 

Hmwk1 due

3 Bish

Tu. Sept. 4

Slides

Ch. 4

Mendel extensions: multiple alleles, dominance epistasis

 

Article: Venter's genome

 

Disc 3 ( 4:15) answers (note: some section 3 took AM quiz)

Quiz 1 Answers.

Disc. 1 (AM) Answers

Disc 2 (Noon) Answers

Ch. 4 guide

Th. Sept. 6

Slides

Ch. 4

Hmwk2 due

Disc Sept. 5

Quiz 1

4 Bish

Tu. Sept. 11
(most given as handout)

Ch. 6

Genetic Linkage, Genetic Mapping


Ch. 6 Guide

Th. Sept. 13
Lec 8 Slides

Ch. 6

 

Disc Sept. 12

Quiz 2 Answer keys

 

5 Bish

Tu. Sept. 18

Lec 9 Slides

Ch. 6

Linkage Mapping cont'd

Whole Genome Mapping

Exam 1 answers

Exam 1 (Ch. 2, 3, 4, part of 6)

Hmwk3 Answers

Th. Sept. 20
Lec 10 Slides

Ch. 6 et al.

 

Disc. Sept. 19

Exam 1

 

6 Bish

Tu. Sept. 25

Lec 11 Slides

Ch. 5

Quantitative Genetics

Quantitative Genetics

 

Retake parts of exam 1

Ch. 5 Guide

Th. Sept. 27
Lec 12 Slides

Ch. 5

Hmwk4 answers
Hmwk Article

Disc. Sept. 26

 

7 Bish

Tu. Oct. 2
Lec 13 slides

Ch. 10

Genetic Material

 

Quiz 3 Disc. 1 answers
Quiz 3 Disc. 2 answers

Quiz 3 Disc. 3 answers


Ch. 10 Guide

Th. Oct. 4
Lec 14 slides

Ch. 10

 

Disc. Oct. 3

Quiz 3

 

8 Bish/Macey

Tu. Oct. 9

Ch. 10

Ch 10: Genetic Material

Ch. 11: Replication

Quiz 4 Disc. 1 answers
Quiz 4 Disc. 2 answers

Quiz 4 Disc. 3 answers

 

 

Th. Oct. 11

Ch. 11

 

Disc. Oct. 10

Quiz 4


9 Macey

Tu. Oct. 16

Ch. 13

Transcription

Exam 2: Ch. 5, 6, 10

Rvw exam answers

 

Th. Oct. 18

Lec. 18

Exam 2

 

Disc. Oct. 17

Review

10 Macey

Oct. 23

Ch. 14

Genetic Code,

Translation

Mutation, Repair, TEs

Reading: Chapter 15: 377-409. Chapter 8: pp 188-196

 

Oct. 25

 

Ch. 14, 15

 

Disc. Oct. 24

 

 

11 Macey

Oct. 30

Ch. 15, 19

Prokaryotic Gene Regulation Reading: Chapter 19 pp 515-532 (Skip phage expression). .Recommended problems.1*, 2*, 4*, 5*, 9, 11, 14, 15*, 17, 18*, 19, 20.

Quiz 5:

 

Nov. 1

Ch. 19

 

Disc. Oct. 31

Quiz 5

 

12 Macey

Nov 6

Ch. 19

Prokaryotic Gene Regulation

Eukaryotic Gene Regulation Reading: Chapter 20: Skip sections on “Operons in Eukaryotes” and “Gene Silencing and Genomic Imprinting”.

 

Nov. 8

Ch. 20

 

Disc. Nov. 7

 

 

 

13 Macey

Nov 13

Ch.20

Exam 3: Transcription, Translation, Mutation & Repair, Gene Regulation

 

Nov. 15

 

Disc. Nov. 14

Exam 3  

14

Nov 20-Nov22

Holiday - Thanksgiving

 

15 Macey

Nov 27

Read Ch. 22

Genes and Cancer

 

Nov. 29

 

Disc. Nov. 28


16 Macey

Dec 4

 

Dec 6

 

Disc Dec 5

 

17

Dec 10-14

Final Exam Week

 

LINKS
National Center for Biotechnology Information (NCBI).  Go here for Medline (bibliographic database), Human Genome Project information, Bioinformatics, and DNA, Protein, and Structural databases.

UCSC Genome Bioinformatics Site

Glossary of genetic terms

FlyLab

Genomes Online. Who has been/is being sequenced? This site has up to date data on genome projects.

Genetics Society of America

Mendel Web An extremely informative web site dedicated to Gregor Mendel.

Mendelian Inheritance in Humans Easily searchable database of simply inherited traits.  Ever heard  a rumor that something is controlled by a single gene (hair ears, tongue curling, etc)? Look it up.

The Biology Project  Has interactive modules on mendelian and molecular genetics, corresponds closely to coverage in Biology 301. Quiz yourself!

 

Last updated: 12/17/07
Comments and questions: bishop_at_vancouver.wsu.edu
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University Information: 360-546-9788